The possible inductions of embryonic diapause with hydrogen-sulfide
Ruf, Maximilian Rudolf Martin
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Recently hydrogen-sulfide has garnered much attention from the scientific community for its potential applications in human medicine. It has been discovered that H2S is able to induce a reversible state of hibernation in laboratory mice by artificially interrupting the electron transfer chain, reducing the metabolic rate of treated cells to the bare minimum. Many researchers see the future of cytoprotective drugs in various forms of hydrogen-sulfide. One of the most promising applications is in the protection of organ transplants from ischemic-reperfusive injuries. The possible extension of the basic idea of hydrogen-sulfide induced hibernation and the concept of hypoxia induced embryonic diapause, which has been proven possible in Zebrafish, has been discussed here for the purpose of introducing the concept off hydrogen-sulfide induced embryonic diapause. As well as a theoretical experiment as prove of the viability of said concept. Through the discovery of its gaseous messenger properties hydrogen-sulfide has become one of the hot topics in todays human medicine be it for its possible application as a hibernation induction agents, its cytoprotective capabilities in response of ischemic reperfusive injuries in kidney or heart patients or in same fashion its probable uses in organ transplants. Current literature however doesn't seem to implicate any possible applications of its many properties in the field of veterinary medicine. Mainly due to the fact that the currently researched fields have no realistic applications for animal treatment because their possible cost far outweigh any lucrative application. However should the experiments proposed here hold any merit it would open op an entirely new field of research into the long term preservation of mammalian embryos. This would be especially interesting if it would make it possible to apply the same success embryo transfers enjoy in the bovine industry today to the swine industry.