Title:A paraffinolaj hatékonyságának vizsgálata lovak tágremese obstipációjának gyógykezelésében
SUMMARY Background: Liquid paraffin is a widely used material worldwide for decades in the treatment of large colon impaction in horses. The efficacy of this treatment option has not been proved by clinical trials in horses. Conversely, there are several reports about the use of liquid paraffin in children, in which this material has proved efficient in the control of idiopathic constipation. On the other hand, there are no studies about efficiency in small animals, except one case report. Objectives: The aim of the current study was to review published data and present a retrospective case series of equine large colon impaction treated with liquid paraffin at the Department and Clinic of Equine Medicine, University of Veterinary Medicine Budapest, between 2015 and 2017. Materials and Methods: Forty-nine adult horses met the inclusion criteria: all animals had rectally palpable large colon impaction at admission. Horses were divided in two groups, the first group was treated with magnesium sulphate and a mixture of different salts (NaCl, KCl and NaHCO3 ) (salt group), and the second one received liquid paraffin beside the aforementioned salts (oil-salt group). Number and duration of treatments, and the amount of administered laxatives were recorded. Results and Discussion: Duration of hospitalisation in each group were compared: the average (mean) time spent at the clinic in the salt group was 3.25 days, and in the oil-salt group was 3.34 days. In this study population we found that there was no significant difference in efficacy of the treatment between the two groups (p = 0.86). Average (mean) hospitalisation period in the oil-salt group was slightly longer, compared to that of the salt group, which may lead us to the conclusion that liquid paraffin could even slow the transit time. In the light of our results, liquid paraffin did not accelerate disimpaction of the large colon in the examined horses.