Title:Változások a C-reaktív protein és a haptoglobin koncentrációjában, valamint egyes hematológiai paraméterekben nőstény kutyáknál fedeztetés előtt, vemhesség alatt és ellés után
SUMMARY Background: Acute phase proteins (APP) are generally used as non-specific markers of inflammation in dogs. The production of APP may be triggered also by physiological factors, for example pregnancy. Objectives: The aim of our study was to compare serum concentrations of C-reactive protein (CRP) and haptoglobin (Hp) between pregnant and non-pregnant bitches. Materials and Methods: We determined serum concentrations of CRP, Hp, haematocrit (HCT), haemoglobin (HGB), erythrocytes (RBC), leukocytes (WBC) and mean corpuscular volume of erythrocytes (MCV) in a group of 25 healthy, non-pregnant bitches. From these animals we formed a subgroup of 6 pregnant bitches. Samples of blood were collected from them before mating during oestrus. Second sampling of blood was performed at days 26−30 of pregnancy and the third one between days 58 and 62 of pregnancy. The fourth, fifth and sixth samplings were performed on days 3, 18 and 33 post-parturition, respectively. Results: Examinations of healthy, non-pregnant bitches showed that concentrations of CRP reached 7.23 ± 4.65 mg/l. Before mating CRP was at the level of 3.2 ± 1.90 mg/l and abruptly increased to 27.91 ± 2.60 mg/l by the second sampling. By the third sampling, CRP decreased to 13.25 ± 4.23 mg/l. On day 3 post-parturition, CRP increased to 14.44 ± 7.92 mg/l. At fifth sampling, CRP concentration decreased to 6.58 ± 2.81 mg/l. At third sampling, Hp decreased almost to the initial level before mating. Differences in concentrations of CRP and Hp at individual samplings were significant (α = 0.05). Discussion: Our investigations showed significant changes in CRP during pregnancy with maximal values reached between days 25 and 30 of pregnancy.