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The effect of the predator odour TMT on the behaviour of mice and the possibility of its epigenetic transmission
dc.contributor.authorBertram, Leonie
dc.date.accessioned2020-03-19T21:46:24Z
dc.date.available2020-03-19T21:46:24Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10832/2407
dc.description.abstractThe accuracy of anxiety studies using live animal trials is constantly challenged by the difficulty to create a controllable and yet easily triggered fear response in the test subjects. We proposed the predator odour 2,4,5-trimethylthiazoline (TMT) as a feasible stimulus to elicit anxiety in mice and investigated its effect. To examine if the fear response was present we used 10% and 100% TMT solutions and several control odours which included citronella as a neutral odour, MHA as an irritating odour, and a perfume as a neutral odour that the mice were acclimated to before the trial. The mice were separately placed in an open field for six-minute time intervals with each odour. In the first half of the six minutes, a hiding box was provided. We analyzed the recordings to find fear-related behaviour: moving away from the odour, hiding, freezing and burying. Additionally, we looked for a change in levels of movement, body position and grooming behaviour.en_US
dc.language.isoenen_US
dc.titleThe effect of the predator odour TMT on the behaviour of mice and the possibility of its epigenetic transmissionen_US
dc.typeThesisen_US


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